UJI SITOTOKSISITAS EKSTRAK KULIT BATANG KALISO SEBAGAI ANTIKANKER TERHADAP LARVA UDANG (Artemia salina, Leach)

Abstract

Cancer is a word that gives the impression to mind everyone will be a terrible pain. In fact, among patients and their families, the diagnosis of cancer is a death sentence, even though not always the case. Until now it is not certain single factor that causes cancer. But some experts agree that cancer is caused by many factors (multifactorial). Based on data from the Ministry of Health (Riskesdas) in 2008, the prevalence of cancer in Indonesia is 4.3 per 1,000 inhabitants. An estimated 12 million people per year affected by cancer. To reduce the cancer patients, the treatment. One alternative, namely the use of natural resources, especially herbs. Kaliso plant (Macaranga tanarius,L) is one of the plants used as traditional medicines. Previous research kaliso bark extract (Macaranga tanarius,L)-capable as an antibacterial, because they contain tannin compounds that act as antioxidants and have effect as a drug. Is kaliso bark extract (Macaranga tanarius, L) has as an anticancer effect against larvae shrimp (Artemia salina,Leach) in vivo? and whether to use a different solvent (ethylacetate, hexane, methanol) extracts of the bark kaliso (Macaranga tanarius,L) gives a different? For that need to be investigated by an early stage cytotoxicity test or preliminary  tests  on  shrimp  larvae  (Artemia  salin Leah) in vivo. This study purpose to determine the ability of the stem bark extract kaliso (Macaranga tanarius, L) as an anticancer against shrimp larvae (Artemia salina, Leach) in vivo, and to determine the ability of the stem bark extract kaliso (Macaranga   tanarius,L)   using  three   solvents  (ethylacetate, hexane, methanol) isdifferent.